Anti-contactin-associated protein-like 2 (CASPR2) encephalitis is characterized by a protracted course, and anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) antibodies induce an often paraneoplastic, treatment-responsive limbic encephalitis which frequently relapses [6–8]. This evidence concerns the gene CNTNAP2 and viral encephalitis.