These so called double expressor (DE) DLBCL are primarily found to be of ABC DLBCL phenotype, suggesting alternative mechanisms responsible for upregulation of BCL2 and MYC protein expression (e.g., chromosomal amplification of the gene BCL2 locus or the activation of the NF-κB pathway) [24]. This evidence concerns the gene BCL2 and aneurysmal bone cyst.