These so called double expressor (DE) DLBCL are primarily found to be of ABC DLBCL phenotype, suggesting alternative mechanisms responsible for upregulation of BCL2 and MYC protein expression (e.g., chromosomal amplification of the gene BCL2 locus or the activation of the NF-κB pathway) [24]. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.