Three recent studies from Asia [80–82] and one from Europe [83•] all concluded that local excision in the form of surgical wedge resection or endoscopic resection is a suitable treatment option for certain type III g-NENs when the following criteria are satisfied: well differentiated histology, low grade (grade 1 and potentially some grade 2 NETs with Ki67 index < 10%), tumour size less than 10 (or possibly 15) mm, depth of invasion confined to the submucosal layer and no evidence of LVI. This evidence concerns the gene MKI67 and neoplasm.