The well-known mutated genes involved in cutaneous melanoma cancerogenesis, unfortunately, have only a marginal role in MM, reporting variable frequencies of mutations, as follows: 7–30% in NRAS, 0–25% in c-KIT, 8–11% in TERT, 3–10% in BRAF (only in one study, 36%), 7% in SF3B1, and KRAS mutations reported only in anecdotic cases [23•]. The gene discussed is KIT; the disease is cutaneous melanoma.