The simultaneous exposure of the melanoma cells to an SMF and the studied flavones caused a statistically significant decrease in the SOD, GPx and CAT activity compared to the control cultures (p = 0.012; p = 0.017; p = 0.019—SMF + Baicalin; p = 0.022; p = 0.019; p = 0.017—SMF + Baicalein). This evidence concerns the gene SOD1 and melanoma.