CREMα also plays a significant role in the downregulation of CD8 from autoreactive CD8+ T cells [82, 96], which may take place in an inflammatory milieu, such as the one seen in spleens of SLE patients due to the lack of the tolerogenic splenic marginal zone macrophages (MZMs) [105]. The gene discussed is CD8A; the disease is systemic lupus erythematosus.