Increased TCR αβ DNTs and autoimmune features were also found in STAT3-GoF, CHAI and X-linked immunodeficiency with magnesium defect, Epstein-Barr virus (EBV) infection, and neoplasia (XMEN), demonstrating that ALPS-U may comprise a wide variety of responsible genes [26, 28, 29]. This evidence concerns the gene STAT3 and autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency.