This third module was composed by temporal brain regions, which is in line with previous studies showing a correlation between amyloid deposition and gray matter loss in temporal areas, which might also be important points of interaction between amyloid pathology and tau pathology, which is known to be one of the drivers of gray matter atrophy in AD (Sepulcre et al. 2016). The gene discussed is MAPT; the disease is amyloidosis.