Moreover, the molecule is reported to exert anti-tumor activity independent of estrogen regulation, exerting its effects via HDAC inhibition, down regulation of tumor promoter genes, human telomerase reverse transcriptase and expression of tumor suppressor genes which explains genetic and epigenetic modes of action which is very important in anti-cancer therapy (Nigam et al., 2010; Nigam et al., 2008; Srivastava et al., 2011; Molinie and Georgel, 2009; Kachchap et al. This evidence concerns the gene HDAC9 and neoplasm.