SRC and cancer: c-Src and EGFR have been shown to enhance pro-mitogenic signals upon epidermal growth factor (EGF) stimuli (Luttrell et al., 1988) c-Src and activated EGFR cooperate to induce cell transformation and cancer development (Maa et al., 1995) by binding to EGFR and thus phosphorylating tyrosine residues on its C-terminal domain, resulting in a variety of downstream effects.