ITCH and neoplasm: Furthermore, hsa-miR-224-5p could be sponged by lncRNA and circRNAs in difference cancers, for instance, by lncNEAT1 in melanoma to promote tumor development [40] or by lncRNA MIR503HG in triple-negative breast cancer to prevent tumor progression [41] or by hsa_circ_0017639 in gastric cancer as a promotor [42] or circ-ITCH in hepatocellular carcinoma as a suppressor [43].