T-cell–derived miR-214 facilitates perivascular fibrosis in hypertension (122), nuclear miR-320 promotes lipid accumulation (hyperlipidemia) in the heart (123), and genome-wide DNA methylation profiling has discovered significant differences in promoter CpG islands in genes like HIF3A, CPT1A, CD38, PHGDH, ABCG1, SREBF1, CPT1A, PDX1 (124). This evidence concerns the gene CPT1A and hypertensive disorder.