Of these targets, c-Jun is reported to associate with Fos-related antigen 1 (Fra1), allowing for its binding to the promoter region of Cdkn1a (coding for p21) and Cdkn2a (coding for p16), and this triggers the senescence-related phenotypes, often seen in many cardiovascular disorders and in vascular senescence (100). Here, CDKN2A is linked to cardiovascular disorder.