Mechanically, vesicular miR-25-3p in colorectal cancer can silence Krüppel-like factor 2 and krüppel-like factor 4, thereby enhancing the expression of vascular endothelial growth factor receptor 2 (VEGFR2) and inhibiting the expression of occludin, zonula occludens-1 and Claudin5 (Zeng et al., 2018). Here, KDR is linked to colorectal cancer.