In this study, we verify that hypermethylated PCDHGB7 can be used to early detect EC by Pap and Tao brush sampling even in EC patients of stage IA without myometrial invasion, G1, tumor < 2 cm in greatest dimension, lymphovascular space invasion (LVSI) (-) and without AUB/PMB (Additional file 2: Supplementary Figure S2). This evidence concerns the gene PCDHGB7 and neoplasm.