Comparison of the positivity rate of autoantibodies against CENPF, ACY1 and the two autoantibodies combined between different stages of liver fibrosis showed significant differences between S4 and S0-1, S4 and S2-3, S4 and S0-3, S2-4 and S0-1 (Figures 3F–J). The gene discussed is ACY1; the disease is Hepatic fibrosis.