In our previous study, we found that autoantibodies against aminoacylase-1 (ACY1), histidine triad nucleotide-binding protein 1 (HINT1), peroxiredoxin 3 (PRDX3), heat shock protein 70 (HSPA6), apoptosis-inducing factor (AIF), regucalcin (RGN), centromere protein F (CENPF) and ENO1 had diagnostic value for distinguishing patients with cirrhosis from chronic hepatitis using serological proteome and protein microarray analyses, with AUC values greater than or close to 0.7 (10, 11). This evidence concerns the gene HINT1 and Cirrhosis.