Pharmacological interventions (prednisolone, melatonin, n-acetylcysteine, noble gas, P-selectin inhibitor, caspase inhibitor, etc.), ischemia preconditioning, and post-ischemic preconditioning, as well as machine perfusion (HMP and NMP) may be effective strategies against liver IRI clinically. Here, SELP is linked to digestive system neoplasm.