Studies have shown that PTP1B promotes the proliferation of colon cancer, breast cancer, and lung cancer by phosphorylating and activating Src (Zhu et al., 2007; Arias-Romero et al., 2009; Liu et al., 2015), a tyrosine kinase containing an SH3 domain. The gene discussed is PTPN1; the disease is malignant colon neoplasm.