In this study, we revealed that MIC-1 inhibits the Src/Ras/Raf/ERK signaling pathway by suppressing the activity of PTP1B, thereby preventing the growth and migration of RCC cells; nevertheless, further investigation is needed to fully elucidate the relationship between PTP1B and the occurrence and development of RCC. Here, PTPN1 is linked to renal cell carcinoma.