For instance, MIC-1 can inhibit the growth of different types of cancer cells by suppressing the NF-κB signaling pathway and increasing the level of glutathione-S-transferase, and was further shown to inhibit the growth of myeloma cells in CD1 mice, also by inhibiting the NF-κB pathway (Brunelli et al., 2010). This evidence concerns the gene HPGDS and plasma cell myeloma.