Similarly, MIC-1 inhibits the growth of SH-SY5Y human neuroblastoma cells in a time- and concentration-dependent manner, and induces SH-SY5Y cell apoptosis and cell cycle arrest by increasing the mRNA and protein levels of P53, P21, Bax, caspase-3, and caspase-9, and blocking the nuclear translocation of NF-κB (Cirmi et al., 2019). Here, CASP3 is linked to neuroblastoma.