Rojas–Rodriguez et al. (Rojas-Rodriguez et al., 2020) reported that insulin resistance is closely associated with endothelial dysfunction (Aziz et al., 2018), and hsa_circ_0010283 is involved in vascular smooth muscle cell dysfunction by regulating the miR-133a-3p/pregnancy-associated plasma protein A (PAPPA) pathway (Feng et al., 2020). Here, PAPPA is linked to endothelial dysfunction.