Among them, most studies showed decreased levels of PINK1 in the context of AD pathology (Choi et al., 2014; Du et al., 2017; Manczak et al., 2018; Reddy et al., 2018; Fang et al., 2019; Ochi et al., 2020; Zhao et al., 2020; Liang et al., 2021), although there are also a minority of studies with opposing conclusions (Mise et al., 2017; Pakpian et al., 2020; Zheng et al., 2020). Here, PINK1 is linked to Alzheimer disease.