Previous research has shown that cytosolic PINK1 fragments enhanced Parkin-mediated ubiquitination and degradation of Parkin substrates in neuroblastoma cells and human brain lysates (Xiong et al., 2009), and bioinformatic analysis presented the potential involvement of Parkin in the ubiquitination of tau (Kumar and Kumar, 2019). Here, PRKN is linked to neuroblastoma.