Among the highly expressed important PRGs, the increased expression levels of POLR2G, PPP2R1A, POLR2L, PRC1, ITGBP1, MARCKSL1, EZH2, DTYMK, and AURKA were accompanied by increased tumor grade (Figure 4A, Supplementary Table S8), which indicated that the RNA abundance of these genes was positively correlated with higher tumor grade and lower tumor differentiation level. Here, POLR2L is linked to neoplasm.