Among them, POLR2L, MARCKSL1, PPP2R1A, POLR2G, and ITGB1BP1 showed the highest expression levels in HCC CSCs, indicating that these five genes may participate in phosphorylation-related pathways in HCC CSCs (Supplementary Figure S4B). The gene discussed is POLR2G; the disease is hepatocellular carcinoma.