We found that different PRGs shared many related genes in the network, and these genes were enriched in cell division, mitotic nuclear division, and DNA replication (Figure 5B), indicating that PRGs might mediate multiple biological processes of tumor stem cells by regulating the expression of cell cycle-related genes such as TOP2A, UBE2C, and CENPN (Figure 5A). Here, UBE2C is linked to neoplasm.