TRPC6 and focal segmental glomerulosclerosis: TRPC6 is a SD-associated protein in podocytes that is involved in regulating glomerular filter function, and gain-of-function mutation in TRPC6 has been associated with the onset of the familial FSGS (Reiser et al., 2005; Winn et al., 2005; Moller et al., 2007).