TAFAZZIN and Barth syndrome: Furthermore, the defects in the biosynthesis of cardiolipin caused by a mutation in the tafazzin (TAZ) gene in Barth syndrome is clinically manifested by cardiomyopathy, skeletal muscle weakness, lactic acidosis, organic aciduria, and growth delay (Ikon and Ryan, 2017b; Falabella et al., 2021; Zegallai and Hatch, 2021).