CXCR3 and acute respiratory distress syndrome: In keeping with this, studies in IP-10/CXCL10-deficient mice demonstrate that the absence of IP-10/CXCL10 reduces disease severity and improves survival in nonviral and viral ARDS models, suggesting that IP-10/CXCL10-CXCR3 signaling worsens ARDS pathology (52).