Limited studies have shown that RETN is positively related to disease severity of sepsis (Sundén-Cullberg et al., 2007; Koch et al., 2009), in which circulating leukocytes increase the expression levels of resistin, and the latter could contribute to disease severity by regulating the expression levels of ICAM-1 and VCAM-1 in vascular endothelial cells (Macdonald et al., 2014; Macdonald et al., 2017). This evidence concerns the gene RETN and Sepsis.