In accordance with the in vitro data, further detailed analysis of the tumor tissues revealed that the MDR1 and proliferating cell nuclear antigen (PCNA) protein levels were decreased, whereas the γH2AX and apoptosis protein Bcl2 levels were upregulated in the mouse tumors upon Gli2 knockdown (Figures 6F, G). The gene discussed is ABCB1; the disease is neoplasm.