Also, overexpression of syncytin-1 in human U251 glioma cells increases the expression of brain-derived neurotrophic factor (BDNF), neurotrophic tyrosine kinase receptor type (NTRK2), and dopamine receptor D3 (DRD3) which contribute to the pathogenesis of the recent-onset SZ at both the mRNA and the protein levels determined by qRT- PCR and western blot (Lewis and Lieberman 2000; Woo et al. 2020). Here, ERVW-1 is linked to central nervous system cancer.