We found that the top ten pathways by p-value (top six) or impact (top four) were indicated the following pathways: glycolysis or gluconeogenesis, fructose, and mannose metabolism, purine metabolism, caffeine metabolism, nicotinate and nicotinamide metabolism, staphylococcus aureus infection, complement and coagulation cascades, HIF-1 signaling, cholesterol metabolism, and phenylalanine metabolism pathways (Figure 3A). Here, HIF1A is linked to staphylococcus aureus infection.