We further analyzed whether the high expression of SERPINH1 was related to the poor prognosis of pan-cancer, and the results showed that high expression of SERPINH1 significantly reduced the OS, DSS, and PFI in 11 types of cancers including ACC, BLCA, CESC, COAD, GBM, HNSC, KIRC, KIRP, LGG, LIHC, and MESO. This evidence concerns the gene SERPINH1 and colon adenocarcinoma.