In this study, the exploratory analysis of SERPINH1 in pan-cancers was carried out in the TCGA database, and the results showed that in both independent samples and paired samples, SERPINH1 were highly expressed in a variety of cancers (including BLCA, BRCA, CHOL, COAD, ESCA, HNSC, KIRC, KIRP, LIHC, LUAD, LUSC, READ, STAD, and UCEC) compared with normal tissues. This evidence concerns the gene SERPINH1 and cancer.