Collectively, these data suggested that TP53 is not only a major player in T cell development and function, but it may also support our current findings suggesting that the TP53/let-7a axis may also negatively regulate Th17 CD4+ subsets, warranting further investigation into the role this protein might be play in the Th17-driven immune response in the PTSD population. This evidence concerns the gene TP53 and post-traumatic stress disorder.