Future studies should and must focus now on evaluating these key findings presented in larger and more diverse patient cohorts, with special emphasis on how types of trauma (e.g. combat vs non-combat) and other factors (e.g. sex or race/ethnicity) might affect the TP53/let-7a axis and the subsequent susceptibility to an inflammatory Th17 phenotype in PTSD patients. Here, TP53 is linked to post-traumatic stress disorder.