PDE12 and viral infectious disease: The most down-modulated genes were related to T helper 2 pathway activation and induction of FOXP3 expression (AREG), immune tolerance (SMAD6) (Figure 3), response to bacterial and viral infection and inflammation (CXCL8, PDE12, STX19, DFNB31), cell transport of glucose and organelles (KIF5A, SCL2A7).