SMAD6 and type 1 diabetes mellitus: In T1D group there were negative correlations of GAD65A and Znt8A levels with two down-regulated DEGs: GAD65A with PDE12(r=-0.57; p=0.03), ZnT8A with PDE12(r=-0.67; p=0.01) and SMAD6 (r=-0.60; p=0.02) and negative correlation of PDE12 with 2’,5’-Oligoadenylate synthetase isoform 3 enzyme (OAS3) (r=-0.517; p= 0.023), related to antiviral response (Figure 5).