The most down-modulated genes were related to T helper 2 pathway activation and induction of FOXP3 expression (AREG), immune tolerance (SMAD6) (Figure 3), response to bacterial and viral infection and inflammation (CXCL8, PDE12, STX19, DFNB31), cell transport of glucose and organelles (KIF5A, SCL2A7). This evidence concerns the gene SMAD6 and viral infectious disease.