Research has demonstrated that the BCAAs and AAAs are positively correlated with body mass index (BMI), waist circumference, visceral fat, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose, insulin and triglyceride levels, and insulin resistance, but inversely linked to high-density lipoprotein-cholesterol (HDL-c) in cross-sectional analyses of large prospective cohort studies (11–15). The gene discussed is INS; the disease is Insulin resistance.