The lack of 68Ga-labeled somatostatin analog uptake in the pituitary gland, along with the elevated serum cortisol and ACTH levels at baseline, suggests that this patient had some degree of cortisol excess at baseline; however, no formal evaluation for Cushing syndrome (eg, urinary free cortisol, dexamethasone suppression testing, or late-night salivary cortisol) was required for enrollment in the oncology study. Here, POMC is linked to Cushing syndrome.