Moreover, Puerarin significantly inhibited the proinflammatory response and oxidative stress in the cerebral cortex and hippocampus by activating PI3K/Akt signaling pathway (Hao et al., 2019) and inhibiting NF-kB activation (Liu et al., 2016), which determines its cognitive protection in diabetes (Yang et al., 2015). This evidence concerns the gene NFKB1 and diabetes mellitus.