More specific to ischemia, corticotropin-releasing hormone knockdown restricted to the hypothalamus led to decreased plasma CORT concentration and more EPM, OFT, and light-dark box exploration (Zhang et al., 2017), while the opposite has been noted upon CRH infusion into the NAcS prior to EPM and OFT (Chen et al., 2012). This evidence concerns the gene CORT and ischemia.