PAX6 and interstitial lung disease: Despite the changes in gene expression induced by the patterning molecules, both euploid and trisomic cells expressed PAX6 in a similar percentage of cells with no significant difference between genotypes when differentiated with either Wnt-C59 (WC p = 0.19, ILD p = 0.99) or RA (WC p = 0.99, ILD p = 0.99; Figures 1G,H).