Lastly, we found no significant difference between euploid and trisomic RA-patterned tNPCs co-expressing OLIG2 and NKX2.2 in either isogenic pair (p = 0.42 WC-24-02-DS and p = 0.90 ILD; Figure 2D; Supplementary Table 4). The gene discussed is NKX2-2; the disease is interstitial lung disease.