In a study investigating the role of miR-19 and RAPGEF2 in schizophrenia using patient-derived hippocampal NPCs (SZ-NPCs), miR-19 was found upregulated in SZ-NPCs, and conservation of the regulation of RAPGEF2 by miR-19 was demonstrated in human embryonic stem cell-derived hippocampal NPCs (Han et al., 2016). Here, RAPGEF2 is linked to schizophrenia.