Interestingly, the same METH-injections paradigm under NAT (22°C) and chronic METH treatments (10 mg/kg, 7 or 14 days) or escalating-dose (2 ∼ 15 mg/kg, 3 days) of METH exposure failed to induce depression-like behaviors. Here, BRD2 is linked to depressive symptom measurement.