NR1H4 and obesity due to melanocortin 4 receptor deficiency: In accordance, FXR deficiency was shown to protect from excessive weight gain in genetic and diet-induced (DIO) obesity models (Prawitt et al., 2011; Zhang et al., 2012), while FXR activation, by peripheral administration of GW4064, potentiated body weight gain and glucose intolerance in DIO mice (Watanabe et al., 2011).