In accordance, FXR deficiency was shown to protect from excessive weight gain in genetic and diet-induced (DIO) obesity models (Prawitt et al., 2011; Zhang et al., 2012), while FXR activation, by peripheral administration of GW4064, potentiated body weight gain and glucose intolerance in DIO mice (Watanabe et al., 2011). This evidence concerns the gene NR1H4 and obesity disorder.