FMR1 and fragile X syndrome: In the brain, astrocytes express FMRP and accumulating evidence suggests widespread alterations in astrocyte-neuronal communication in FXS models (Pacey and Doering, 2007; Jacobs and Doering, 2010; Jacobs et al., 2012, 2016; Yang et al., 2012; Pacey et al., 2015; Cheng et al., 2016; Sourial and Doering, 2016; Wallingford et al., 2017; Krasovska and Doering, 2018).