TRPV3 and Olmsted syndrome 1: In humans, gain-of-function genetic mutations of TRPV3 cause Olmsted syndrome, which is clinically characterized by diffuse palmoplantar keratoderma, alopecia, and skin inflammation (Poulin et al., 1984; Lucker and Steijlen, 1994; Nofal et al., 2010; Lai-Cheong et al., 2012).