The importance of glucose in the central nervous system is supported by the cognitive deficits and loss of consciousness that accompany hypoglycemia and reduced glucose transport to the brain (Abdul Muneer et al., 2011; Mergenthaler et al., 2013; Patching, 2017), as seen in the GLUT1 deficiency syndrome: a genetic disorder characterized by a deficiency in the facilitative glucose transporter 1 (GLUT1) responsible for shuttling glucose across the blood-brain barrier (Heilig et al., 2003; Marin-Valencia et al., 2012; Yu et al., 2020). The gene discussed is SLC2A1; the disease is Hypoglycemia.