For example, when examining infiltrated triple-negative breast cancer (TNBC) tumors, we found the median ratio of PD-1+ to PD-L1+ immune cells to be near unity (Fig. 4f) and the prevalence of PD-1 or Lag3 positive lymphocytes to be 13.9% and 5.5% on average, respectively (Fig. 4e). This evidence concerns the gene PDCD1 and triple-negative breast carcinoma.