PPP3CA and major depressive disorder: After excluding genes within the major histocompatibility complex (MHC; chr6: 25–34 Mb), which was particularly relevant to pairs PSC-MDD and PSC-SCZ in various tissues, we identified three non-MHC TWAS susceptibility genes (NR5A2, SATB2, PPP3CA) from analyses Single-tissueconditional to be shared between brain (SCZ, CD, UC: Hypothalamus; SCZ, UC: Frontal cortex BA9; SCZ, CD: Putamen basal ganglia) and intestinal tissues (CD, UC: Colon transversum; UC: Colon sigmoideum; CD: Colon transversum) (Table 2; more detailed results in Supplementary Data 3).