Interestingly, GO Human Phenotype analysis of the upregulated genes in 2-mo Pcyt2+/− liver (Fig. 2C) identified a disease network between Insulin-resistant Diabetes and Maternal Diabetes and Hypoalphalipoproteinemia (HDL lipoprotein deficiency), Hyperuricemia, Polydipsia, Rhabdomyosarcoma and immunity (Asthma and Complement deficiency). The gene discussed is PCYT2; the disease is insulin-resistant diabetes mellitus.