NUS1P3 and neoplasm: Of these, the promoter regions of three genes (MIR124-2, RP11-713P17.4, and NUS1P3) were hypermethylated in BBM and three genes (MIR3193, CTD-2023M8.1 and MTND6P4) were hypomethylated in BBM relative to the primary tumours (Fig. 2C,D).