MTND6P4 and neoplasm: This CoBRA analysis identifed three genes that were frequently methylated in BP and infrequently methylated in BBM tumours; CTD-2023M8.1, MIR3193 and MTND6P4 were methylated in 26%, 29% and 0% of BBM samples respectively (n = 30) (Fig. 2B–D, and Supplementary Fig. 4D–F, S11A-C) and were methylated in 63%, 67% and 47% non-metastatic BP respectively (n = 20) (Fig. 2B–D Supplementary Fig. 4D-F).