When compared between IDH mutant and wild-type gliomas based on their pathological diagnoses, without considering MRI labels, HIF1a-positive cell percentage, GLUT3-positive cell percentage, and HK2-positive cell percentage were significantly higher in IDH wild-type than in IDH mutant gliomas (9.51% ± 7.11% vs. 3.84% ± 3.38%, P < 0.01 for HIF1a; 3.28% ± 4.61% vs. 1.17% ± 3.32%, P < 0.05 for GLUT3; and 7.23% ± 14.54% vs. 0.14% ± 0.25%, P < 0.05 for HK2). Here, HIF1A is linked to central nervous system cancer.