AKT1S1 and neoplasm: However, only two tumors formed in shPGK1+Myc-PRAS40 T246A group, and the tumor volume and weight were downregulated greatly compared to that of the shPGK1+Myc-PRAS40 group (P < 0.05), but not different from that of the PGK1-knockdown group (Fig. 3K, L).