Phosphorylation is considered as the active form of PRAS40, lots of phosphorylation sites in the C-terminal region are responsible for growth factor stimulation and nutrients [18, 19], and Thr246 hyperphosphorylation has been found in the clinical specimens of HCC, prostate cancer, melanoma, and non-small cell lung cancer [13, 20, 21]. This evidence concerns the gene AKT1S1 and hepatocellular carcinoma.