To determine whether GDF15 regulates the expression of C-C chemokines in bone cells, we assessed the mRNA expression of C-C chemokines (CCL2, CCL3, CCL7, and CCL12) in osteoblasts following treatment with either rhGDF15 or conditioned medium (CM) collected from different PCa cells. The gene discussed is GDF15; the disease is posterior cortical atrophy.