LIPA and obesity due to melanocortin 4 receptor deficiency: Obesity activates lysosome biogenesis, which is involved in lipolysis in eWAT, such as in the expression of the vacuolar (H+)-ATPase ATP6V0d2, the structural lysosome protein lysosome-associated membrane protein 2 (LAMP2), and the acid lipase called lipase A (LIPA)25.