Obesity activates lysosome biogenesis, which is involved in lipolysis in eWAT, such as in the expression of the vacuolar (H+)-ATPase ATP6V0d2, the structural lysosome protein lysosome-associated membrane protein 2 (LAMP2), and the acid lipase called lipase A (LIPA)25. The gene discussed is LIPA; the disease is obesity disorder.