The production of anti-Dsg1 and anti-Dsg3 by healthy individuals is known; therefore, the presence of anti-Dsg2 in the FPF, FPV, and CTL groups would not exclude its participation in the pathogenesis of PF and PV.19, 20, 21 Anti-Dsg2 titers correlated with those of anti-Dsg1 in PF (r = 0.1628; p = 0.0206), also reported by Flores et al. (2012);17 however, there was no correlation of anti-Dsg2 with anti-Dsg3 in PV. This evidence concerns the gene DSG3 and acquired polycythemia vera.