DSG2 and pemphigus: Concluding this discussion, the expression of Dsg2 in tissues other than the skin is known, such as lung, gastrointestinal, renal, and myocardial tissues.5, 8 Thus, corroborating that anti-Dsg2 antibodies are not pathogenic, there is no evidence of involvement of internal organs in pemphigus, with the exception of the esophagus in the PV group.24