To contribute to the understanding of Dsg2 participation in the pathogenesis of pemphigus, the production of autoantibodies against Dsg 1, 2 and 3 were compared in a large sample of patients with PF and PV, their family members, and healthy controls living in the northeast region of the state of São Paulo, Brazil, where both PF and PV are prevalent. Here, DSG2 is linked to pemphigus foliaceus.