In contrast to the expressions of Dsg1 and Dsg3, which are restricted to stratified epithelia, Dsg2 is widely expressed in all epithelia containing desmosomes, including pulmonary, gastrointestinal, renal and myocardial tissues, and in the skin, ovarian, lung and stomach tumors.5, 6, 7, 8, 9, 10, 11 In human skin, Dsg2 is poorly expressed, being restricted to the basal layer of the epidermis, while its expression resembles the expressions of Dsg1 and Dsg3 in immortalized squamous cell carcinoma cell lines.12 The gene discussed is DSG2; the disease is gastric neoplasm.