Our finding that there is no reduction of VENs and phylogenetically related neurons in the ACC, combined with predominantly AD-typical patterns of neurodegeneration [12, 19, 20, 22], and the lack of consistent regional difference in tau pathology between bvAD and tAD [24, 26, 51] may suggest more diffuse neurobiological mechanisms to underlie the behavioral alterations in bvAD. This evidence concerns the gene MAPT and Alzheimer disease.