The experiment of subcutaneously transplanted tumor in nude mice showed that the tumorigenesis ability of SiHa cells after knockout STAT3 was significantly weaker than that of control cells (Fig. 2F), and the expression of STAT3 in tumor tissue of nude mice detected by western blotting was consistent with that of tumorigenesis (Fig. 2G). The gene discussed is STAT3; the disease is neoplasm.